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Friday, August 17, 2018

Undifferentiated connective tissue disease Top #6 Facts - YouTube
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Mixed connective tissue disease (also known as Sharp's syndrome), commonly abbreviated as MCTD, is an autoimmune disease characterized by the presence of high blood levels of a specific autoantibody, now called anti-U1 ribonucleoprotein (RNP). The idea behind the "mixed" disease is that this specific autoantibody is also present in other autoimmune diseases such as systemic lupus erythematosus, polymyositis, scleroderma, etc. It was characterized in 1972, and the term was introduced by Leroy in 1980.

It is sometimes said to be the same as undifferentiated connective tissue disease, but other experts specifically reject this idea because undifferentiated connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms.


Video Mixed connective tissue disease



Signs and symptoms

MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome.

MCTD commonly causes:

  • joint pain/swelling,
  • malaise,
  • Raynaud phenomenon,
  • muscle inflammation, and
  • sclerodactyly (thickening of the skin of the pads of the fingers)

Maps Mixed connective tissue disease



Causes

It has been associated with HLA-DR4.


Mixed Connective Tissue Disease, how does it affect the body ...
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Diagnosis

Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody.


Mixed Connective Tissue Disease Ppt â€
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Treatment

  • Corticosteroids (0.5 mg/kg body weight)
  • Hydroxychloroquine (HCQ)
  • Methotrexate
  • Plasmapheresis

103P Polymyositis, Dermatomyositis, Inclusion body myositis, Mixed ...
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Prognosis

The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite of prednisone treatment, this disease is progressive and may in many cases evolve into a progressive systemic sclerosis (PSS), also referred to as diffuse cutaneous systemic scleroderma (dcSSc) which has a poor outcome. In some cases though the disease is mild and may only need aspirin as a treatment and may go into remission where no Anti-U1-RNP antibodies are detected, but that is rare or within 30% of cases. Most deaths from MCTD are due to heart failure caused by pulmonary arterial hypertension (PAH).


Mixed Connective Tissue Disease Causes, Symptoms, Treatment
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See also

  • Autoimmunity
  • Overlap syndrome

Connective tissue disorders 1 - YouTube
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References


Mixed Connective Tissue Disease Ppt â€
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Further reading


Mixed Connective Tissue Disease mnemonic - YouTube
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External links

Source of the article : Wikipedia

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